Whatever your matrix, we have adequate solutions for your biomarker analysis
In pharmaceutical development, biomarkers assume a central role being one of the most important parameters to confirm mechanism of action, monitor disease progress, assess drug efficacy, investigate safety and perform pharmacokinetic / pharmacodynamic (PK / PD) modelling.
Our biomarker services
IBR Inc. has longstanding experience in biomarker assessment under GxP quality standards in accordance with regulations (EMA, FDA, ICH). The IBR Inc. facility is equipped with GxP compliant sample management system, central monitoring of storage conditions, state-of-the-art data security and latest immune platform technologies to support your biomarker project from pre-clinical to all phases of clinical development.
IBR Inc. offers testing of protein biomarkers (e.g. cytokines, chemokines, enzymes, hormones, growth factors, antibodies and many others…), as well as biomarker measurement on mRNA / cDNA level in cells and/or in tissues. We are able to detect secreted markers in a broad variety of matrices like cell culture supernatants, serum, plasma and all other body fluids, membrane-bound markers, intracellular markers (e.g. cell phenotyping by FACS) and biomarkers expressed in the extracellular matrix (e.g. by IHC). We provide flexibility for:
- Development & validation of assays customized to your specific needs
- Adaption of commercial available kits to your requirements & validation
- Transfer of your methods and validation for subsequent use in clinical studies under GCP
Our technologies for biomarker testing
To provide flexible solutions for singleplex and multiplex biomarker testing IBR Inc. offers a broad variety of methods and technologies:
- Immunoassays - ranging from advanced technologies like Meso Scale, Gyrolab and Alpha Technology to classical methods like ELISA and ELISpot
- Flow Cytometry
- Cell-based Assays (including primary cells, cell lines and 3D-cell systems)
- Quantitative PCR in single or multiplex format
- Immunohistochemistry (IHC)
- Western blot
Carefully selecting the appropriate platform can improve success. IBR Inc. sets high value on intense scientific discussions to identify your needs and aims, ensuring the proper choice of technology platform.