Service Overview


Our Focus...

Cell-Based Assays

Development and validation of cell-based assays for analysing the potency of Biologics or Small Molecules is in the focus of our expertise.

Standard assay types are...

  • Cell proliferation
  • Inhibition of cell proliferation
  • Cytotoxicity
  • Apoptosis
  • ADCC assay
  • CDC assay
  • Migration
  • Adhesion
  • Opsonophagocytosis
  • Biomarker expression
  • Cytokine release
  • Intracellular cytokines
  • Receptor-binding assays
  • Gene Expression assays

Vaccines

  • T-cell immune response after vaccination
  • B-cell immune response after vaccination
  • Clinical studies: Cellular and humeral immunology and functional in vitro tests
  • Activation of innate immune system
  • Human PBMCs (isolation, proliferation, cytotoxicity, phenotyping, cytokine release, gene expression)
  • Potency testing of polyvalent pneumococcal vaccines by the UAB-OPA

PK/ADA

  •  Analysis of Biologics (antibodies, proteins) in animal and human samples (Method Development, Validation, Sample Analysis) according to GLP
  •  Anti-Drug-Antibody Assays in animal and human samples (Method Development, Validation, Sample Analysis) according to GLP
  •  Neutralising Antibodies testing
  •  In-vitro bioequivalence studies according to Draft FDA guidelines for phosphate and bile acid adsorbents (proprietary 96 well plate assays replacing HPLC analytical determination  

Biomarkers

  • Biomarker expression (RNA/Protein) in fluids, tissue sections, biopsies
  • Biomarker induction by cytokines

Enzymes

  • Hemolytic assay
  • Coagulation assays 
  • Complement assays: CH50, different complement ELISAs (human, rat, mouse)
  • Enzyme activities: e.g. PLA, serine protease, elastase, peroxidase

Host Cell Proteins

  • Generic and Host Cell Specific ELISA: Method Development, Validation, Sample Analysis
  • 2 D Gel Western blot

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